Trifluoroacetic acid → HCID 178511557, compound

HRID 731464Notes

Reaction equation

HRID 731464 reaction equation
C(OC(=O)[NH:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([CH2:14][O:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH2:10][CH2:9]1)(C)(C)C.[F:23][C:24]([F:29])([F:28])[C:25]([OH:27])=[O:26]>ClCCl>[F:23][C:24]([F:29])([F:28])[C:25]([OH:27])=[O:26].[O:15]([CH2:14][C@H:11]1[CH2:12][CH2:13][C@H:8]([NH2:7])[CH2:9][CH2:10]1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178453951HCID 178453951, compound

Product 1

HCID 178511557HCID 178511557, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

380 mg of (trans-4-phenoxymethyl-cyclohexyl)-carbamic acid tert-butyl ester is dissolved in 5 mL of dichloromethane and 5 ml of trifluoroacetic acid is added. The mixture is stirred for 2 h, concentrated in vacuo and stripped twice from dichloromethane to afford 250 mg of trans-4-phenoxymethylcyclohexylamine trifluoroacetate as a white solid.

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-e20eea23693847f4a2342f14a130a385
Source dataset
uspto-grants-2009_09
Patent number
US07582769B2

Reaction notes

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