反应详情

The product from step (g) (0.3 g) was suspended in a mixture of dioxan (50 ml) and conc.HCl (1 ml). Water (1 ml) was added and the resultant solution heated at 60° C. for 12 hours. Allowed to stand over weekend. Solvents removed in vacuo and residue taken up in water. Yellow precipitate collected by filtration and washed with water. Purified using prep. Hplc Acetonitrile: 0.1% ammonium acetate (90:10 to 95:5) over 25 minutes to give 0.063 g of the desired product. 22% yield.

1. waitAllowed to stand over weekend
2. customSolvents removed in vacuo and residue
3. filtrationYellow precipitate collected by filtration
4. washwashed with water
5. customPurified