Hydrochloric Acid → HCID 59186669, compound

HRID 731550Notes

Reaction equation

HRID 731550 reaction equation
[CH3:1][O:2][C:3]1([CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=2[CH3:29])[CH2:8][CH2:7][CH:6]([N:9]2[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]2)[CH2:5][CH2:4]1.Cl>ClCCl.C(OCC)C>[CH3:1][O:2][C:3]1([CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=2[CH3:29])[CH2:4][CH2:5][CH:6]([N:9]2[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]2)[CH2:7][CH2:8]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 59186703HCID 59186703, compound

Product 1

HCID 59186669HCID 59186669, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

A solution of EXAMPLE 15D (0.51 g, 1.26 mmol) in dichloromethane (5 mL) at room temperature was treated with 2M HCl in diethyl ether (5 mL), stirred overnight, and concentrated to provide the desired product (0.38 g, 100%). MS (ESI) m/e 303 (M+H)+.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-c3cb7b80b60949d4ba2d12c0b487f348
Source dataset
uspto-grants-2009_09
Patent number
US07585858B2

Reaction notes

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