4-Aminotetrahydropyran → HCID 24738511, compound

HRID 731625Notes

Reaction equation

HRID 731625 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[C:13]1[N:14]=[C:15]2[CH:20]=[C:19]([C:21]([OH:23])=O)[CH:18]=[CH:17][N:16]2[CH:24]=1.[NH2:25][CH:26]1[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1>>[O:29]1[CH2:30][CH2:31][CH:26]([NH:25][C:21]([C:19]2[CH:18]=[CH:17][N:16]3[CH:24]=[C:13]([C:3]4[C:4]([C:7]5[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=5)=[N:5][O:6][C:2]=4[CH3:1])[N:14]=[C:15]3[CH:20]=2)=[O:23])[CH2:27][CH2:28]1

Participants

3

Reactant 2

HCID 4192234-AminotetrahydropyranHCID 69067892HCID 69067892, compound

Product 1

HCID 24738511HCID 24738511, compoundYield 57%

Procedure

As described for Example 11b, 2-(5-methyl-3-phenyl-isoxazol-4-yl)-imidazo[1,2-a]pyridine-7-carboxylic acid (85 mg, 0.27 mmol) was converted, using 4-aminotetrahydropyran instead of aminomethylcyclopropane, to the title compound (61 mg, 57%) which was obtained as a yellow solid. MS: m/e=403.5 [M+H]+.

Sources & evidence

ORD record
ord-36100dbd07df40ec848adefb9b1711f1
Source dataset
uspto-grants-2009_09
Patent number
US07585874B2

Reaction notes

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