2-Amino-5-chloropyridine → HCID 24738991, compound

HRID 731634Notes

Reaction equation

HRID 731634 reaction equation
Br[CH2:2][C:3]([C:5]1[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[N:7][O:8][C:9]=1[CH3:10])=O.[NH2:17][C:18]1[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][N:19]=1>>[Cl:24][C:21]1[CH:22]=[CH:23][C:18]2[N:19]([CH:2]=[C:3]([C:5]3[C:6]([C:11]4[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=4)=[N:7][O:8][C:9]=3[CH3:10])[N:17]=2)[CH:20]=1

Participants

3

Reactant 2

HCID 661742-Amino-5-chloropyridineHCID 27355314-(Bromoacetyl)-5-methyl-3-phenylisoxazole

Product 1

HCID 24738991HCID 24738991, compoundYield 53%

Procedure

As described for Example 1, 4-(bromoacetyl)-5-methyl-3-phenylisoxazole (commercially available) (140 mg, 0.5 mmol) was converted, using 2-amino-5-chloropyridine instead of 2-aminopyridine, to the title compound (82 mg, 53%) which was obtained as a yellow gum. MS: m/e=310.3[M+H]+.

Sources & evidence

ORD record
ord-b183fcedb85f44629f372d02523b21ec
Source dataset
uspto-grants-2009_09
Patent number
US07585874B2

Reaction notes

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