Methylamine → HCID 57838010, compound

HRID 732091Notes

Reaction equation

HRID 732091 reaction equation
[CH3:1][NH2:2].Cl[CH2:4][C:5]1[N:9]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([Cl:16])[CH:11]=2)[O:7][N:6]=1>CCO>[Cl:16][C:12]1[CH:11]=[C:10]([C:8]2[O:7][N:6]=[C:5]([CH2:4][NH:2][CH3:1])[N:9]=2)[CH:15]=[CH:14][CH:13]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 100825203-(Chloromethyl)-5-(3-chlorophenyl)-1,2,4-oxadiazole

Product 1

HCID 57838010HCID 57838010, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

MeNH2 in EtOH (6 mL, 8 M, 48 mmol) was added to 3-(chloromethyl)-5-(3-chlorophenyl)-1,2,4-oxadiazole (1.5 g, 6.5 mmol) in EtOH (20 mL). After 20 h the solvent was evaporated and the residue was dried in vacuum to give 1.47 g (100%) of the title compound. LC-MS (M++1): 224

Workup

  1. customAfter 20 h the solvent was evaporated
  2. customthe residue was dried in vacuum

Sources & evidence

ORD record
ord-4f65c854b1d24dd886049e2784158b3b
Source dataset
uspto-grants-2009_09
Patent number
US07585881B2

Reaction notes

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