反应详情

A solution of 750 mg (3.1 mmol) (1,4,5,6-tetrahydro-pyrimidin-2-yl)-hydrazine hydroiodide (Krezel, Izabella; Pharmazie; 1994; p. 27-31) and 552 mg (3.1 mmol) isonicotinoyl chloride hydrochloride in 3 ml pyridine was heated at 120° C. o.n. The reaction mixture was cooled and diluted with aq. sat. K2CO3 and extracted with chloroform. The combined organic extracts were dried and concentrated. Flash chromatography (DCM/MeOH 10:1) afforded 83 mg (18%) of the title compound. 1H NMR: 1.91 (m, 2 H) 3.24 (m, 2 H) 4.13 (m, 2 H) 7.67 (m, 2 H) 8.65 (m, 2 H)

1. temperatureThe reaction mixture was cooled
2. extractionextracted with chloroform
3. customThe combined organic extracts were dried
4. concentrationconcentrated