反应详情

While 77.0 g of 2-bromo-1-(4-methoxy-phenyl)-3-methyl-butan-1-one (4) prepared in Example 2 were added to 200 ml of ethanol and stirred, 42.7 g of thioacetamide were added. Subsequently, the temperature was gradually increased and stirring under reflux was continued for 22 hr. After the reaction was completed, the resultant reaction mixture was added with 300 ml of ethylacetate, and then washed with a saturated aqueous solution of potassium carbonate. The ethylacetate layer was dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure, thus obtaining 35.8 g (yield: 51.0%) of a title compound as brown liquid.

1. temperatureSubsequently, the temperature was gradually increased
2. stirringstirring
3. temperatureunder reflux
4. customthe resultant reaction mixture
5. washwashed with a saturated aqueous solution of potassium carbonate
6. dry with materialThe ethylacetate layer was dried over anhydrous magnesium sulfate
7. concentrationconcentrated under reduced pressure