反应详情

Add anhydrous sodium sulfite (16.8 g, 130 mmol) to a solution of 4-chlorobutyl acetate (20.0 g, 133 mmol) in water (50 mL) and reflux the mixture for 20 h. Cool to room temperature and add concentrated HCl (19.0 mL) and reflux for 1 h. Cool the mixture to room temperature, neutralize to about pH=7. Concentrate to about one half the volume, filter away the sodium chloride. Concentrate and dry to give the title compound.

1. temperaturereflux the mixture for 20 h
2. temperaturereflux for 1 h
3. temperatureCool the mixture to room temperature
4. concentrationConcentrate to about one half the volume
5. filtrationfilter away the sodium chloride
6. concentrationConcentrate
7. customdry