Hydrochloric Acid → HCID 68815198, compound

HRID 732600Notes

Reaction equation

HRID 732600 reaction equation
C(OC([N:8]1[CH2:12][C@H:11]([O:13][C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([O:20][CH3:21])[CH:15]=2)[CH2:10][C@@H:9]1[C@@H:22]([OH:37])[C@@H:23]([NH:33][C:34](=[O:36])[CH3:35])[CH2:24][C:25]1[CH:30]=[C:29]([F:31])[CH:28]=[C:27]([F:32])[CH:26]=1)=O)(C)(C)C.[ClH:38]>O1CCOCC1>[ClH:38].[F:31][C:29]1[CH:30]=[C:25]([CH:26]=[C:27]([F:32])[CH:28]=1)[CH2:24][C@H:23]([NH:33][C:34](=[O:36])[CH3:35])[C@H:22]([OH:37])[C@H:9]1[CH2:10][C@@H:11]([O:13][C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([O:20][CH3:21])[CH:15]=2)[CH2:12][NH:8]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68816253HCID 68816253, compound

Product 1

HCID 68815198HCID 68815198, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

React (2R,4R)-2-[(1S,2S)-2-Acetylamino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-4-(3-methoxy-phenoxy)-pyrrolidine-1-carboxylic acid tert-butyl ester With 4M HCl in dioxane essentially as described in EXAMPLE 1 to provide the title compound.

Sources & evidence

ORD record
ord-6af6eefc63cc4a13bb28cec3798c4226
Source dataset
uspto-grants-2009_09
Patent number
US07585885B2

Reaction notes

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