Hydrochloric Acid → HCID 131727624, compound

HRID 732608Notes

Reaction equation

HRID 732608 reaction equation
[ClH:1].O1CCOCC1.C(OC([N:15]1[CH2:19]/[C:18](=[CH:20]\[C:21]([O:23][CH3:24])=[O:22])/[CH2:17][C@@H:16]1[C@H:25]1[O:29]C(C)(C)[N:27]([C:32](=[O:34])[CH3:33])[C@H:26]1[CH2:35][C:36]1[CH:41]=[C:40]([F:42])[CH:39]=[C:38]([F:43])[CH:37]=1)=O)(C)(C)C>>[ClH:1].[CH3:24][O:23][C:21](=[O:22])/[CH:20]=[C:18]1\[CH2:19][NH:15][C@@H:16]([C@@H:25]([OH:29])[C@@H:26]([NH:27][C:32](=[O:34])[CH3:33])[CH2:35][C:36]2[CH:41]=[C:40]([F:42])[CH:39]=[C:38]([F:43])[CH:37]=2)[CH2:17]\1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 68818146HCID 68818146, compound

Product 1

HCID 131727624HCID 131727624, compoundYield 93%

Procedure

Add HCl 4M in dioxane (0.861 mL, 3.4 mmol) to (R)-2-[(4S,5S)-3-Acetyl-4-(3,5-difluoro-benzyl)-2,2-dimethyl-oxazolidin-5-yl]-4-[1-methoxycarbonyl-meth-(Z)-ylidene]-pyrrolidine-1-carboxylic acid tert-butyl ester (0.024 g, 0.046 mmol). Stir overnight. Concentrate under reduced pressure to provide the title compound (0.021 g, 93%).

Workup

  1. concentrationConcentrate under reduced pressure

Sources & evidence

ORD record
ord-f37ddd30d69f42b8bee6653ec278a1b7
Source dataset
uspto-grants-2009_09
Patent number
US07585885B2

Reaction notes

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