Hydrochloric Acid → HCID 68818090, compound

HRID 732616Notes

Reaction equation

HRID 732616 reaction equation
[ClH:1].C(OC([N:9]1[CH2:13][C@H:12]([O:14][CH2:15][CH2:16][C:17]([OH:20])([CH3:19])[CH3:18])[CH2:11][C@@H:10]1[C@H:21]1[O:25]C(C)(C)[N:23]([C:28](=[O:30])[CH3:29])[C@H:22]1[CH2:31][C:32]1[CH:37]=[C:36]([F:38])[CH:35]=[C:34]([F:39])[CH:33]=1)=O)(C)(C)C>O1CCOCC1>[ClH:1].[F:38][C:36]1[CH:37]=[C:32]([CH:33]=[C:34]([F:39])[CH:35]=1)[CH2:31][C@H:22]([NH:23][C:28](=[O:30])[CH3:29])[C@H:21]([OH:25])[C@H:10]1[CH2:11][C@@H:12]([O:14][CH2:15][CH2:16][C:17]([OH:20])([CH3:19])[CH3:18])[CH2:13][NH:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68815214HCID 68815214, compound

Product 1

HCID 68818090HCID 68818090, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Add 4M hydrogen chloride in dioxane (5 mL) to (2R,4R)-2-[(4S,5S)-3-acetyl-4-(3,5-difluoro-benzyl)-2,2-dimethyl-oxazolidin-5-yl]-4-(3-hydroxy-3-methyl-butoxy)-pyrrolidine-1-carboxylic acid tert-butyl ester (0.11 g, 0.207 mmol). Stir 4 hours and evaporate to give the title compound as a foam (0.102 g, 100%).

Workup

  1. customevaporate

Sources & evidence

ORD record
ord-338c2d09530b440594b9f97ea381dc24
Source dataset
uspto-grants-2009_09
Patent number
US07585885B2

Reaction notes

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