Trifluoroacetic acid → HCID 601794, compound

HRID 732633Notes

Reaction equation

HRID 732633 reaction equation
[OH:1][C:2]1[CH:12]=[CH:11][C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[CH:4][CH:3]=1.Br[CH2:14][C:15]([O:17]C(C)(C)C)=[O:16].C(O)(C(F)(F)F)=O>ClCCl>[CH2:9]([O:8][C:6]([C:5]1[CH:4]=[CH:3][C:2]([O:1][CH2:14][C:15]([OH:17])=[O:16])=[CH:12][CH:11]=1)=[O:7])[CH3:10]

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 8434EthylparabenHCID 79177tert-Butyl bromoacetate

Product 1

HCID 601794HCID 601794, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Ethyl 4-(2-tert-butyl-2-oxoethyl)benzoate obtained by carrying out reaction of ethyl 4-hydroxybenzoate with tert-butyl bromoacetate in the same manner as in Reference Example 23 (1) was dissolved in dichloromethane, mixed with TFA at room temperature and stirred overnight at room temperature. By evaporating the solvent, [4-(ethoxycarbonyl)phenoxy]acetic acid was obtained as a white solid. EN: 223.

Workup

  1. customBy evaporating the solvent

Sources & evidence

ORD record
ord-139a1cd6459247e395cbeaaa0c1a0458
Source dataset
uspto-grants-2009_09
Patent number
US07585886B2

Reaction notes

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