Hydrochloric Acid → 2-oxo-4-phenylpyrrolidine-3-carboxylic acid

HRID 732658Notes

Reaction equation

HRID 732658 reaction equation
[OH-].[Na+].[O:3]=[C:4]1[CH:8]([C:9]([O:11]CC)=[O:10])[CH:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:6][NH:5]1.Cl>CO>[O:3]=[C:4]1[CH:8]([C:9]([OH:11])=[O:10])[CH:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:6][NH:5]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 313653ethyl 2-oxo-4-phenylpyrrolidine-3-carboxylate

Product 1

HCID 28368682-oxo-4-phenylpyrrolidine-3-carboxylic acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1 M sodium hydroxide aqueous solution was added at room temperature to a methanol solution of ethyl 2-oxo-4-phenylpyrrolidine-3-carboxylate (Wako Pure Chemical Industries (Wako), Japan) and stirred for 13Hours. The reaction solution was acidified by adding 1 M hydrochloric acid, and the thus precipitated solid was collected by filtration and dried to obtain 2-oxo-4-phenylpyrrolidine-3-carboxylic acid. FP: 206.

Workup

  1. filtrationthe thus precipitated solid was collected by filtration
  2. customdried

Sources & evidence

ORD record
ord-96a333b29e1447fbb71a448f4acc9a4e
Source dataset
uspto-grants-2009_09
Patent number
US07585886B2

Reaction notes

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