Hydrochloric Acid → 1-Benzyl-5-oxo-pyrrolidine-3-carboxylic acid

HRID 732665Notes

Reaction equation

HRID 732665 reaction equation
[CH2:1]([N:8]1[C:12](=[O:13])[CH2:11][CH:10]([C:14]([O:16]C)=[O:15])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+].Cl>CO>[CH2:1]([N:8]1[C:12](=[O:13])[CH2:11][CH:10]([C:14]([OH:16])=[O:15])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 98909Methyl 1-benzyl-5-oxopyrrolidine-3-carboxylate

Product 1

HCID 990241-Benzyl-5-oxo-pyrrolidine-3-carboxylic acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

A methanol solution of methyl 1-benzyl-5-oxo-3-pyrrolidinecarboxylate was mixed with 1 M sodium hydroxide aqueous solution and stirred at room temperature for 2Hours. After completion of the reaction, this was neutralized with 1 M hydrochloric acid, and methanol was evaporated. The thus formed crystals were collected by filtration to obtain 1-benzyl-5-oxo-3-pyrrolidine-carboxylic acid. FN: 218.

Workup

  1. customAfter completion of the reaction
  2. customwas evaporated
  3. filtrationThe thus formed crystals were collected by filtration

Sources & evidence

ORD record
ord-12ea58761fb44df1822d118733376ac4
Source dataset
uspto-grants-2009_09
Patent number
US07585886B2

Reaction notes

Loading…