Triethylamine → 1-Benzyl-5-oxopyrrolidine-3-carboaldehyde

HRID 732669Notes

Reaction equation

HRID 732669 reaction equation
C(N(CC)CC)C.[CH2:8]([N:15]1[CH2:19][CH:18]([CH2:20][OH:21])[CH2:17][C:16]1=[O:22])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>CS(C)=O>[CH2:8]([N:15]1[C:16](=[O:22])[CH2:17][CH:18]([CH:20]=[O:21])[CH2:19]1)[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 1788241-Benzyl-4-(hydroxymethyl)pyrrolidin-2-one

Product 1

HCID 722996181-Benzyl-5-oxopyrrolidine-3-carboaldehyde

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

Triethylamine and a pyridine-sulfur trioxide complex were added to a DMSO solution of 1-benzyl-4-(hydroxymethyl)pyrrolidin-2-one and stirred at room temperature for 2Hours. Thereafter, its work-up and purification were carried out in the standard method to obtain 1-benzyl-5-oxopyrrolidine-3-carboaldehyde. EI: 203.

Workup

  1. customThereafter, its work-up and purification

Sources & evidence

ORD record
ord-06587b7bb10048a493338260c3185964
Source dataset
uspto-grants-2009_09
Patent number
US07585886B2

Reaction notes

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