反应详情

Combine 2-(3-fluoro-4-methanesulfonyl-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane (222 mg, 0.74 mmol), NalO4 (474 mg, 2.2 mmol), tetrahydrofuran (THF, 4 mL) and water (1 mL). Stir for 2 hours and add 2M HCl in diethyl ether (0.2 mL). Stir another 12 hours and filter away the solid. Wash the filtrate with brine (10 mL), dry with MgSO4 and evaporate the solvent. Wash the solid with hexane (2×10 mL) and ether (10 mL). Dry the solid under vacuum to obtain 68 mg of the title compound (42%).

1. stirringStir another 12 hours
2. filtrationfilter away the solid
3. washWash the filtrate with brine (10 mL)
4. dry with materialdry with MgSO4
5. customevaporate the solvent
6. washWash the solid with hexane (2×10 mL) and ether (10 mL)
7. customDry the solid under vacuum