Bis(2-bromoethyl) ether → Tert-butyl 4-cyanooxane-4-carboxylate

To a stirred suspension of NaH (17.7 g, 0.443 mol) in N,N-dimethylformamide (200 mL) was added dropwise a solution of tert-butyl cyanoacetate (25.0 g, 0.177 mol) in N,N-dimethylformamide (100 mL) at 0° C. under N2. The mixture was allowed to warm up to ambient temperature, and stirred for 1 h. Then, bis(2-bromoethyl)ether (49.3 g, 0.177 mol) was added to the mixture, and the resulting mixture was stirred at 90° C. for 24 h. After cooling to 0° C., the mixture was washed with water (100 mL). The volatile components were removed by evaporation and the residue was precipitated with a mixture of ethyl acetate-toluene (1:2, 500 mL) and water (500 mL). The organic phase was washed with water (500 mL) three times, dried over Na2SO4, filtered and evaporated. The solid was washed with hexane, collected by filtration and dried in vacuo to give 19.0 g (57%) of the title compound as white crystal.

1. stirringthe resulting mixture was stirred at 90° C. for 24 h
2. temperatureAfter cooling to 0° C.
3. washthe mixture was washed with water (100 mL)
4. customThe volatile components were removed by evaporation
5. customthe residue was precipitated with a mixture of ethyl acetate-toluene (1:2, 500 mL) and water (500 mL)
6. washThe organic phase was washed with water (500 mL) three times
7. dry with materialdried over Na2SO4
8. filtrationfiltered
9. customevaporated
10. washThe solid was washed with hexane
11. filtrationcollected by filtration
12. customdried in vacuo

ORD record

ord-8405dda2ecee4d45ac91a4ce34124032

Source dataset

uspto-grants-2009_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07589109B2