反应详情

To a solution of 3-Amino-5-bromobenzotrifluoride (200 mg) in pyridine (2 mL) was added methane sulphonyl chloride (115 mg) and one crystal of 4-(dimethyl-amino)pyridine. The mixture was stirred at room temperature for four hours then diluted with ethyl acetate (50 mL) and washed with HCl (2M, 50 mL) and saturated sodium chloride solution (50 mL). Organics were separated, dried over sodium sulphate, filtered, and solvent was removed under reduced pressure to yield N-(3-bromo-5-trifluoromethyl-phenyl)-methanesulfonamide (264 mg).

1. washwashed with HCl (2M, 50 mL) and saturated sodium chloride solution (50 mL)
2. customOrganics were separated
3. dry with materialdried over sodium sulphate
4. filtrationfiltered
5. customsolvent was removed under reduced pressure