Hydrochloric Acid → HCID 178504707, compound

HRID 733378Notes

Reaction equation

[C:1]([C:3]1[CH:4]=[CH:5][C:6]([OH:36])=[C:7]([S:9]([NH:12][CH2:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[S:27]([CH3:30])(=[O:29])=[O:28])=[CH:17][C:16]=2[O:31][CH2:32][C:33]([O-:35])=[O:34])(=[O:11])=[O:10])[CH:8]=1)#[N:2].[Na+].[NH2:38][OH:39].Cl>O>[OH:36][C:6]1[CH:5]=[CH:4][C:3]([C:1](=[NH:2])[NH:38][OH:39])=[CH:8][C:7]=1[S:9]([NH:12][CH2:13][CH2:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2[S:27]([CH3:30])(=[O:29])=[O:28])=[CH:17][C:16]=1[O:31][CH2:32][C:33]([OH:35])=[O:34])(=[O:10])=[O:11]

Participants

Conditions

Temperature: 70 °C

Procedure

Method 2) To a stirred solution of 117 g of sodium [4-[2-(5-cyano-2-hydroxybenzenesulfonylamino)ethyl]-2′-methanesulfonylbiphenyl-3-yloxy]acetate in 1.17 L of water was added 56 g of 50% aqueous hydroxylamine solution at room temperature, and the mixture was stirred at 70° C. for 4 hours. To the reaction mixture was added dropwise 1 mol/L hydrochloric acid at room temperature, and the mixture was stirred at the same temperature over night. The obtained solid was collected by filtration to give 110 g of [4-[2-[2-hydroxy-5-(N-hydroxy-carbamimidoyl)benzenesulfonylamino]ethyl]-2′-methane-sulfonylbiphenyl-3-yloxy]acetic acid.

Workup

stirringthe mixture was stirred at the same temperature over night
filtrationThe obtained solid was collected by filtration

Sources & evidence

ORD record: ord-36d0bb2e28b04ae0ba40095b3818b157
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07589126B2

Reaction notes

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