反应详情

tert-butyl methyl[(1-{2-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]ethyl}-2,3-dihydro-1H-inden-1-yl)methyl]carbamate (0.7425 g, 1.404 mmole) was dissolved in 2 ml of DCM and 2 ml of 4M HCl in dioxane. After stirring the reaction was neutralized with saturated NaHCO3 and extracted with Et2O to afford N-methyl(1-{2-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]ethyl}-2,3-dihydro-1H-inden-1-yl)methanamine (0.21 g, 35% yield).

1. extractionextracted with Et2O