反应详情

To a solution of sodium-p-aminosalicylate (100 g, 0.65 mol) in 10% aqueous NaOH solution (1 L) was added a 50% wt solution of benzyl chloroformate (670 g, 1.96 mol in toluene) at 0° C. and stirred at rt for 48 h. The reaction mixture was cooled and acidified with a 10% aqueous HCl at 0° C. The solid obtained was filtered and washed with cold water and dried. The solid was treated with PetEther and filtered to give the title compound (129 g, 68%) used in the next steps without further purification.

1. temperatureThe reaction mixture was cooled
2. customThe solid obtained
3. filtrationwas filtered
4. washwashed with cold water
5. customdried
6. additionThe solid was treated with PetEther
7. filtrationfiltered