Cyanoacetic acid → HCID 57841361, compound

HRID 733574Notes

Reaction equation

HRID 733574 reaction equation
[CH2:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]#[C:12][C:13]2[CH:33]=[CH:32][C:16]([CH2:17][NH:18][CH2:19][C:20]3[CH:31]=[CH:30][C:23]([O:24][CH2:25][C:26]([O:28][CH3:29])=[O:27])=[CH:22][CH:21]=3)=[CH:15][CH:14]=2)=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4].[C:34]([CH2:36][C:37](O)=[O:38])#[N:35]>>[CH2:1]([C:5]1[CH:6]=[CH:7][C:8]([C:11]#[C:12][C:13]2[CH:14]=[CH:15][C:16]([CH2:17][N:18]([CH2:19][C:20]3[CH:21]=[CH:22][C:23]([O:24][CH2:25][C:26]([O:28][CH3:29])=[O:27])=[CH:30][CH:31]=3)[C:37](=[O:38])[CH2:36][C:34]#[N:35])=[CH:32][CH:33]=2)=[CH:9][CH:10]=1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 9740Cyanoacetic acidHCID 57554567Methyl {4-[({4-[(4-butylphenyl)ethynyl]benzyl}amino)methyl]phenoxy}acetate

Product 1

HCID 57841361HCID 57841361, compound

Procedure

The titled compound was prepared following the procedure H using methyl {4-[({4-[(4-butylphenyl)ethynyl]benzyl}amino)methyl]phenoxy}acetate and cyanoacetic acid, as a pale yellow oil (96%). M− (ESI): 507.4; M+ (ESI): 509.4. HPLC, Rt: 5.22 min (Purity: 86.2%).

Sources & evidence

ORD record
ord-d6a6e985af924e6aab5630848b472da7
Source dataset
uspto-grants-2009_09
Patent number
US07589232B2

Reaction notes

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