Sodium Hydroxide → HCID 11167834, compound

HRID 733575Notes

Reaction equation

HRID 733575 reaction equation
[CH2:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]#[C:12][C:13]2[CH:38]=[CH:37][C:16]([CH2:17][N:18]([CH2:24][C:25]3[CH:36]=[CH:35][C:28]([O:29][CH2:30][C:31]([O:33]C)=[O:32])=[CH:27][CH:26]=3)[C:19](=[O:23])[CH2:20][C:21]#[N:22])=[CH:15][CH:14]=2)=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4].[OH-].[Na+]>CN(C=O)C>[CH2:1]([C:5]1[CH:6]=[CH:7][C:8]([C:11]#[C:12][C:13]2[CH:38]=[CH:37][C:16]([CH2:17][N:18]([CH2:24][C:25]3[CH:26]=[CH:27][C:28]([O:29][CH2:30][C:31]([OH:33])=[O:32])=[CH:35][CH:36]=3)[C:19](=[O:23])[CH2:20][C:21]#[N:22])=[CH:15][CH:14]=2)=[CH:9][CH:10]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 57841361HCID 57841361, compound

Product 1

HCID 11167834HCID 11167834, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The titled compound was prepared following the procedure F using methyl (4-{[{4-[(4-butylphenyl)ethynyl]benzyl}(cyanoacetyl)amino]methyl}phenoxy)acetate and NaOH 1 N in the presence of DMF, as a white powder (20%). M− (ESI): 493.3; M+ (ESI): 495.3. HPLC, Rt: 5.01 min (Purity: 80.6%).

Sources & evidence

ORD record
ord-dff3919179c84895a4f0e6f60948ae44
Source dataset
uspto-grants-2009_09
Patent number
US07589232B2

Reaction notes

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