Hydrochloric Acid → HCID 68867321, compound

HRID 733695Notes

Reaction equation

HRID 733695 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[N:10]=[CH:11][C:12]([C:19]([N:21]3[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]3)=[O:20])=[C:13]3[C:17]([CH3:18])=[CH:16][NH:15][C:14]=23)[CH:5]=[CH:6][CH:7]=1.Cl>C(OCC)(=O)C.C(OCC)C>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[N:10]=[CH:11][C:12]([C:19]([N:21]3[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]3)=[O:20])=[C:13]3[C:17]([CH3:18])=[CH:16][NH:15][C:14]=23)[CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 44475668HCID 44475668, compound

Product 1

HCID 68867321HCID 68867321, compoundYield 169.9%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherCatalystHCID 8857Ethyl AcetateSolvent

Procedure

1-[7-(3-Chloro-phenylamino)-3-methyl-1H-pyrrolo[2,3-c]pyridin-4-yl]-1-piperidin-1-yl-methanone (60 mg) was suspended in warm ethyl acetate (10 ml) and treated with a solution of 1M hydrochloric acid in diethyl ether (10 drops). The mixture was evaporated and dried at 40° C. under vacuum to afford the title compound (56 mg).

Workup

  1. customThe mixture was evaporated
  2. customdried at 40° C. under vacuum

Sources & evidence

ORD record
ord-4171eb2c3ca9450db5183c42cbace4f7
Source dataset
uspto-grants-2009_09
Patent number
US07589206B2

Reaction notes

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