Hydrochloric Acid → HCID 68867211, compound

HRID 733698Notes

Reaction equation

HRID 733698 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:9][C:10]2[N:11]=[CH:12][C:13]([C:20]([N:22]3[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]3)=[O:21])=[C:14]3[C:18]([CH3:19])=[CH:17][NH:16][C:15]=23)[CH:6]=[CH:7][CH:8]=1.[ClH:28]>C(OCC)(=O)C.C(OCC)C>[ClH:28].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:9][C:10]2[N:11]=[CH:12][C:13]([C:20]([N:22]3[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]3)=[O:21])=[C:14]3[C:18]([CH3:19])=[CH:17][NH:16][C:15]=23)[CH:6]=[CH:7][CH:8]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 57840939HCID 57840939, compound

Product 1

HCID 68867211HCID 68867211, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherCatalystHCID 8857Ethyl AcetateSolvent

Procedure

1-[7-(3-Methoxy-phenylamino)-3-methyl-1H-pyrrolo[2,3-c]pyridin-4-yl]-1-piperidin-1-yl-methanone (50 mg) was suspended in warm ethyl acetate (10 ml) and treated with a solution of 1M hydrochloric acid in diethyl ether (10 drops). The mixture was evaporated and dried at 40° C. under vacuum to afford the title compound (47 mg).

Workup

  1. customThe mixture was evaporated
  2. customdried at 40° C. under vacuum

Sources & evidence

ORD record
ord-5e57b434f9cb458a8b65565f280ba172
Source dataset
uspto-grants-2009_09
Patent number
US07589206B2

Reaction notes

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