Hydrochloric Acid → HCID 68868184, compound

HRID 733709Notes

Reaction equation

HRID 733709 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[N:10]=[CH:11][C:12]([C:20]([N:22]3[CH2:27][CH2:26][O:25][CH2:24][CH2:23]3)=[O:21])=[C:13]3[C:17]([CH3:18])=[CH:16][N:15]([CH3:19])[C:14]=23)[CH:5]=[CH:6][CH:7]=1.[ClH:28]>C(O)C.C(OCC)C>[ClH:28].[F:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[N:10]=[CH:11][C:12]([C:20]([N:22]3[CH2:23][CH2:24][O:25][CH2:26][CH2:27]3)=[O:21])=[C:13]3[C:17]([CH3:18])=[CH:16][N:15]([CH3:19])[C:14]=23)[CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 57840894HCID 57840894, compound

Product 1

HCID 68868184HCID 68868184, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherCatalystHCID 702EthanolSolvent

Procedure

1-[7-(3-Fluoro-phenylamino)-1,3-dimethyl-1H-pyrrolo[2,3-c]pyridin-4-yl]-1-morpholin-4-yl-methanone (73 mg) was dissolved in warm ethanol (12 ml) and treated with a solution of 1M hydrochloric acid in diethyl ether (10 drops) The mixture was evaporated, triturated with diethyl ether and filtered off then dried at 40° C. under vacuum to afford the title compound (65 mg).

Workup

  1. customwas evaporated
  2. customtriturated with diethyl ether
  3. filtrationfiltered off
  4. customthen dried at 40° C. under vacuum

Sources & evidence

ORD record
ord-3f055bfb55c140ce889b5e2eaef9359d
Source dataset
uspto-grants-2009_09
Patent number
US07589206B2

Reaction notes

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