Hydrochloric Acid → HCID 68869906, compound

HRID 733713Notes

Reaction equation

HRID 733713 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[N:11]=[CH:12][C:13]([C:21]([N:23]3[CH2:28][CH2:27][O:26][CH2:25][CH2:24]3)=[O:22])=[C:14]3[C:18]([CH3:19])=[CH:17][N:16]([CH3:20])[C:15]=23)[CH:5]=[C:6]([F:8])[CH:7]=1.[ClH:29]>C(O)C.C(OCC)C>[ClH:29].[F:8][C:6]1[CH:5]=[C:4]([NH:9][C:10]2[N:11]=[CH:12][C:13]([C:21]([N:23]3[CH2:24][CH2:25][O:26][CH2:27][CH2:28]3)=[O:22])=[C:14]3[C:18]([CH3:19])=[CH:17][N:16]([CH3:20])[C:15]=23)[CH:3]=[C:2]([F:1])[CH:7]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 57841022HCID 57841022, compound

Product 1

HCID 68869906HCID 68869906, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherCatalystHCID 702EthanolSolvent

Procedure

1-[7-(3,5-Difluoro-phenylamino)-1,3-dimethyl-1H-pyrrolo[2,3-c]pyridin-4-yl]-1-morpholin-4-yl-methanone (24 mg) was dissolved in warm ethanol (5 ml) and treated with a solution of 1M hydrochloric acid in diethyl ether (10 drops) The mixture was evaporated, triturated with diethyl ether and filtered off then dried at 40° C. under vacuum to afford the title compound (20 mg).

Workup

  1. customwas evaporated
  2. customtriturated with diethyl ether
  3. filtrationfiltered off
  4. customthen dried at 40° C. under vacuum

Sources & evidence

ORD record
ord-7b39ef28c16b4eeb910a8651b45411d3
Source dataset
uspto-grants-2009_09
Patent number
US07589206B2

Reaction notes

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