反应详情

温度

75 °C

To a solution of 1H-indole-3-carbonitrile (0.28 g) in dimethyl sulfoxide (3 mL) were added 3-iodobenzoic acid ethyl ester (0.61 g), cesium carbonate (0.65 g), copper iodide (0.038 g) and N,N-dimethyl grycine (0.041 g), this mixture was stirred at 75° C. for 3 days. To this reaction mixture was added ethyl acetate, the insoluble material was removed by filtration and this filtrate was concentrated under reduced pressure. To this residue was added water, the precipitated solid was collected by filtration, and washed with water and n-hexane, and dried under reduced pressure at 40° C. to give the title compound (0.38 g).

1. customthe insoluble material was removed by filtration
2. concentrationthis filtrate was concentrated under reduced pressure
3. additionTo this residue was added water
4. filtrationthe precipitated solid was collected by filtration
5. washwashed with water and n-hexane
6. customdried under reduced pressure at 40° C.