Potassium Carbonate → HCID 11955931, compound

HRID 734194Notes

Reaction equation

HRID 734194 reaction equation
C([O:4][CH2:5][C:6]([N:8]1[CH2:13][CH2:12][O:11][CH:10]2[CH2:14][N:15]([C:17]3[CH:22]=[CH:21][C:20]([N:23]4[CH2:27][CH:26]([CH2:28][NH:29][C:30](=[O:32])[CH3:31])[O:25][C:24]4=[O:33])=[CH:19][C:18]=3[F:34])[CH2:16][CH:9]12)=[O:7])(=O)C.C(=O)([O-])[O-].[K+].[K+]>CO>[F:34][C:18]1[CH:19]=[C:20]([N:23]2[CH2:27][CH:26]([CH2:28][NH:29][C:30](=[O:32])[CH3:31])[O:25][C:24]2=[O:33])[CH:21]=[CH:22][C:17]=1[N:15]1[CH2:16][CH:9]2[CH:10]([O:11][CH2:12][CH2:13][N:8]2[C:6](=[O:7])[CH2:5][OH:4])[CH2:14]1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 11955926HCID 11955926, compound

Product 1

HCID 11955931HCID 11955931, compoundYield 55.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To the compound 2-[6-(4-{5-[(acetylamino)methyl]-2-oxo-1,3-oxazolidin-3-yl}-2-fluorophenyl)hexahydropyrrolo[3,4-b][1,4]oxazin-4(4aH)-yl]-2-oxoethyl acetate (590 mg) obtained from Example 06 above in methanol (15 ml) was added potassium carbonate (0.34 g) and stirred for overnight. The reaction mixture was filtered, concentrated and purified by column using 3% methanol in dichloromethane as eluant to yield the title compound (300 mg).

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationconcentrated
  3. custompurified by column

Sources & evidence

ORD record
ord-1098451a5b0c4eea9c453311b60708b9
Source dataset
uspto-grants-2009_09
Patent number
US07592335B2

Reaction notes

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