Hydrochloric Acid → HCID 68816388, compound

HRID 734331Notes

Reaction equation

HRID 734331 reaction equation
[CH:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]([CH:12]2[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]2)=[O:11])[C@@H:6]([CH3:25])[CH2:5]1)([CH3:3])[CH3:2].[ClH:26]>CO>[ClH:26].[ClH:26].[CH:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]([CH:12]2[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]2)=[O:11])[C@@H:6]([CH3:25])[CH2:5]1)([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68817055HCID 68817055, compound

Product 1

HCID 68816388HCID 68816388, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

(S)-1-Isopropyl4-[1-(tert-butoxycarbonyl)-piperidine4-carbonyl]-3-methylpiperazine (D22)(0.11 g) was dissolved in methanol (10 ml) and treated with HCl (4N HCl in diethyl ether; 10 ml). After being stirred at rt overnight the reaction mixture was evaporated to a minimum, co-evaporated from methanol, and then dried at 50° C. to give the title compound (D23) as a pale brown solid (0.10 g)

Workup

  1. customwas evaporated to a minimum
  2. customdried at 50° C.

Sources & evidence

ORD record
ord-c42219a49a334b25b3cc10e4cd520de6
Source dataset
uspto-grants-2009_09
Patent number
US07592347B2

Reaction notes

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