Hydrochloric Acid → (S)-1-isopropyl-4-(piperidine-4-carbonyl)-2-methylpiperazine dihydrochloride

HRID 734335Notes

Reaction equation

[CH:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]([CH:12]2[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]2)=[O:11])[CH2:6][C@@H:5]1[CH3:25])([CH3:3])[CH3:2].[ClH:26]>>[ClH:26].[ClH:26].[CH:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]([CH:12]2[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]2)=[O:11])[CH2:6][C@@H:5]1[CH3:25])([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 68818623(S)-1-isopropyl-4-[1-(tert-Butoxycarbonyl)-piperidine-4-carbonyl]-2-methyl piperazine

Product 1

HCID 68817427(S)-1-isopropyl-4-(piperidine-4-carbonyl)-2-methylpiperazine dihydrochloride

Procedure

(S)-1-Isopropyl-4-[1-(tert-butoxycarbonyl)-piperidine-4-carbonyl]-2-methyl-piperazine (D28)(3.8 g) was treated with HCl as described in Description 8 step 4 to give the title dihydrochloride (D29) as a white solid (2.5 g). LCMS electrospray (+ve) 254 (MH+).

Sources & evidence

ORD record: ord-16f4f6702ce24916a36e8702dc9189cd
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07592347B2

Reaction notes

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