Triethylamine → HCID 69055678, compound

HRID 734380Notes

Reaction equation

HRID 734380 reaction equation
[CH2:1]([N:8]1[CH2:13][CH:12]2[C:10](CO)([CH2:11]2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(CC)CC)C.[CH3:23][S:24](Cl)(=[O:26])=[O:25]>C(OCC)(=O)C>[CH2:1]([N:8]1[CH2:13][CH:12]2[C:10]([S:24]([CH3:23])(=[O:26])=[O:25])([CH2:11]2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 69060340HCID 69060340, compound

Product 1

HCID 69055678HCID 69055678, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
0 °C

Procedure

To a solution of 3-benzyl-1-hydroxymethyl-3-azabicyclo[3.1.0]hexane in ethyl acetate were added triethylamine (2.15 gm, 0.02125 mole) and methane sulphonylchloride (1.947 gm, 0.017 mole). The mixture was stirred at 0° C. for 1 hour. The reaction was quenched by the addition of saturated NaHCO3. The separated organic layer was washed with water, brine, dried and evaporated to give the crude product, which was used as such for further reaction.

Workup

  1. customThe reaction was quenched by the addition of saturated NaHCO3
  2. washThe separated organic layer was washed with water, brine
  3. customdried
  4. customevaporated

Sources & evidence

ORD record
ord-c0f31c62e68f4988aab85ee8e27e8d16
Source dataset
uspto-grants-2009_09
Patent number
US07592359B2

Reaction notes

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