反应详情

To a suspension of the compound of Example 1 (120 mg, 0.6 mmol) and potassium carbonate (246 mg, 1.8 mmol) in dimethylformamide (4 ml) was added chloromethyl pivalate (215 μl, 1.5 mmol) and the reaction mixture stirred at room temperature overnight. Water (10 ml) was added and the mixture then extracted with ethyl acetate (2×10 ml). The organic layers were combined, washed with water (10 ml) and brine (10 ml), dried (MgSO4) and concentrated in vacuo.

1. extractionthe mixture then extracted with ethyl acetate (2×10 ml)
2. washwashed with water (10 ml) and brine (10 ml)
3. dry with materialdried (MgSO4)
4. concentrationconcentrated in vacuo