BROMINE CHLORIDE (BrCl) → HCID 11598674, compound

HRID 734819Notes

Reaction equation

HRID 734819 reaction equation
CS(O[CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]#[C:16][C:17]2[C:22]([Br:23])=[CH:21][C:20]([C:24]3[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][CH:25]=3)=[CH:19][N:18]=2)=[CH:11][CH:10]=1)(=O)=O.[CH3:31][CH:32]1[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]1.BrCl>>[Br:23][C:22]1[C:17]([C:16]#[C:15][C:12]2[CH:13]=[CH:14][C:9]([O:8][CH2:7][CH2:6][N:35]3[CH2:36][CH2:37][CH:32]([CH3:31])[CH2:33][CH2:34]3)=[CH:10][CH:11]=2)=[N:18][CH:19]=[C:20]([C:24]2[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][CH:25]=2)[CH:21]=1

Participants

4

Reactant 3

HCID 61697BROMINE CHLORIDE (BrCl)2×HCID 693814-MethylpiperidineHCID 866011362-{4-[3-Bromo-5-(4-chlorophenyl)pyridin-2-ylethynyl]phenoxy}ethyl methanesulfonate

Product 1

HCID 11598674HCID 11598674, compound

Procedure

The product was obtained analogously to Example 7.1g starting from 2-{4-[3-bromo-5-(4-chlorophenyl)pyridin-2-ylethynyl]phenoxy}ethyl methanesulfonate and 4-methylpiperidine. Yield: 0.15 g (88% of theoretical); C27H26BrClN2O (M=509.865); calc.: molpeak (M+H)+: 509/511/513 (BrCl); found: molpeak (M+H)+: 509/511/513 (BrCl); HPLC-MS: 6.11 minutes (method A).

Workup

  1. custom6.11 minutes (method A)

Sources & evidence

ORD record
ord-d489ea53f8714d32a264a680867b3f81
Source dataset
uspto-grants-2009_09
Patent number
US07592358B2

Reaction notes

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