Trimethylsilylacetylene → HCID 69058638, compound

HRID 734827Notes

Reaction equation

HRID 734827 reaction equation
Br[C:2]1[C:7]([Cl:8])=[CH:6][C:5]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=2)=[CH:4][N:3]=1.[CH3:16][Si:17]([C:20]#[CH:21])([CH3:19])[CH3:18]>>[Cl:8][C:7]1[C:2]([C:21]#[C:20][Si:17]([CH3:19])([CH3:18])[CH3:16])=[N:3][CH:4]=[C:5]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=2)[CH:6]=1

Participants

3

Reactant 2

HCID 66111TrimethylsilylacetyleneHCID 86077064HCID 86077064, compound

Product 1

HCID 69058638HCID 69058638, compound

Procedure

The product was obtained analogously to Example 7.1b starting from 2-bromo-3-chloro-5-(4-chlorophenyl)pyridine and trimethylsilylacetylene. Yield: 0.57 g (quant. yield); C16H15Cl2NSi (M=320.288); calc.: molpeak (M+H)+: 320/322/324 (2Cl); found: molpeak (M+H)+: 320/322/324 (2Cl); HPLC-MS: 8.02 minutes (method B).

Workup

  1. customThe product was obtained analogously to Example 7.1b
  2. custom8.02 minutes (method B)

Sources & evidence

ORD record
ord-2d2e0db962c34f0eb58ae17f70a2f6c7
Source dataset
uspto-grants-2009_09
Patent number
US07592358B2

Reaction notes

Loading…