5-(4-Chloro-phenyl)-2-ethynyl-pyridine → HCID 69058833, compound

HRID 734877Notes

Reaction equation

HRID 734877 reaction equation
I[C:2]1[CH:7]=[CH:6][C:5]([C:8]2([OH:14])[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]2[CH:23]=[CH:24][C:25]([C:28]#[CH:29])=[N:26][CH:27]=2)=[CH:18][CH:17]=1>CCOC(C)=O>[Cl:15][C:16]1[CH:17]=[CH:18][C:19]([C:22]2[CH:23]=[CH:24][C:25]([C:28]#[C:29][C:2]3[CH:7]=[CH:6][C:5]([C:8]4([OH:14])[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]4)=[CH:4][CH:3]=3)=[N:26][CH:27]=2)=[CH:20][CH:21]=1

Participants

4

Reactant 2

HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridineHCID 69056726HCID 69056726, compound

Product 1

HCID 69058833HCID 69058833, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The product was obtained analogously to Example 7.1e starting from 4-(4-iodophenyl)piperidin-4-ol and 5-(4-chlorophenyl)-2-ethynylpyridine. Yield: 0.78 g (61% of theoretical); C24H21ClN2O (M=388.889); calc.: molpeak (M+H)+:389/391 (Cl); found: molpeak (M+H)+:389/391 (Cl); Rf value: 0.86 (silica gel, EtOAc/cyc 4:1).

Workup

  1. customThe product was obtained analogously to Example 7.1e

Sources & evidence

ORD record
ord-668af006bef34e57a59f884c43f6774a
Source dataset
uspto-grants-2009_09
Patent number
US07592358B2

Reaction notes

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