2-Amino-5-bromopyrazine → HCID 22248974, compound

HRID 734886Notes

Reaction equation

HRID 734886 reaction equation
Br[C:2]1[N:3]=[CH:4][C:5]([NH2:8])=[N:6][CH:7]=1.[Cl:9][C:10]1[CH:15]=[CH:14][C:13](OB(O)O)=[C:12]([CH3:20])[CH:11]=1>CCOC(C)=O>[Cl:9][C:10]1[CH:15]=[CH:14][C:13]([C:2]2[N:3]=[CH:4][C:5]([NH2:8])=[N:6][CH:7]=2)=[C:12]([CH3:20])[CH:11]=1

Participants

4

Reactant 2

HCID 5995392-Amino-5-bromopyrazineHCID 69063338HCID 69063338, compound

Product 1

HCID 22248974HCID 22248974, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The product was prepared analogously to Example 48.1a from 2.61 g (15.0 mmol) of 5-bromopyrazin-2-ylamine and 2.56 g (15.0 mmol) of 4-chloro-2-methylphenylboric acid. Yield: 1.70 g (52% of theoretical); C11H10ClN3 (M=219.670); calc.: molpeak (M+H)+:220/222 (Cl); found: molpeak (M+H)+:220/222 (Cl); Rf value: 0.35 (silica gel, PE/EtOAc 7:3).

Sources & evidence

ORD record
ord-97d07e8aee87498595e29665c65ffd68
Source dataset
uspto-grants-2009_09
Patent number
US07592358B2

Reaction notes

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