Piperidine → HCID 68816419, compound

HRID 734997Notes

Reaction equation

HRID 734997 reaction equation
CS(O[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]#[C:14][C:15](=[O:31])[NH:16][C:17]2[CH:22]=[CH:21][C:20](C3C=CC(OC)=CC=3)=[CH:19][CH:18]=2)=[CH:9][CH:8]=1)(=O)=O.[NH:32]1[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]1.ClCCl.[CH2:41]([OH:43])C>>[CH3:41][O:43][C:20]1[CH:19]=[CH:18][C:17]([NH:16][C:15](=[O:31])[C:14]#[C:13][C:10]2[CH:9]=[CH:8][C:7]([CH2:6][N:32]3[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]3)=[CH:12][CH:11]=2)=[CH:22][CH:21]=1

Participants

4

Reactant 3

HCID 8082PiperidineHCID 21584144Dichloromethane ethanolHCID 86601886HCID 86601886, compound

Product 1

HCID 68816419HCID 68816419, compound

Procedure

Prepared analogously to Example 1.2.c. from 4-[(4′-methoxybipheny-4-ylcarbamoyl)ethynyl]benzyl methanesulfonate and piperidine. Yield: 5 mg (18.8% of theory); melting point: 170° C.; C28H28N2O2 (M=424.54); calc.: molecular ion peak (M+H)+: 425; found: molecular ion peak (M+H)+: 425; Rf value: 0.28 (silica gel, dichloromethane/ethanol (20:1)).

Workup

  1. customPrepared analogously to Example 1.2.c

Sources & evidence

ORD record
ord-32460f4dc0864001925a784b5517f447
Source dataset
uspto-grants-2009_09
Patent number
US07592373B2

Reaction notes

Loading…