Piperidine → 1-(4-Iodobenzyl)piperidine

HRID 735016Notes

Reaction equation

HRID 735016 reaction equation
[I:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Br)=[CH:4][CH:3]=1.[NH:10]1[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1>ClCCl.C(O)C>[I:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][N:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 8082PiperidineHCID 9542584-Iodobenzyl bromide

Product 1

HCID 75376001-(4-Iodobenzyl)piperidine

Reagents, catalysts & solvents 1

HCID 21584144Dichloromethane ethanolSolvent

Procedure

Prepared analogously to Example 1.1 c. from 4-iodobenzyl bromide and piperidine. Yield: 0.85 g (67% of theory); C12H16IN (M=301.17); calc.: molecular ion peak (M+H)+: 322; found: molecular ion peak (M+H)+: 302; Rf value: 0.55 (silica gel, dichloromethane/ethanol (20:1)).

Workup

  1. customPrepared analogously to Example 1.1 c

Sources & evidence

ORD record
ord-ca48e2c9a86d4e9f9c7524ebd61ae45c
Source dataset
uspto-grants-2009_09
Patent number
US07592373B2

Reaction notes

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