HRID73514

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8471

Triethylamine

C6H15N

HCID2735781

4-Chloro-3-nitropyridine

C5H3ClN2O2

结构：CC(C)(C)OC(=O)N[C@@H]1CNCC[C@H]1O[Si](C)(C)C(C)(C)C

HCID68922675

rel-1,1-Dimethylethyl N-[(3R,4R)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-piperidinyl]carbamate

C16H34N2O3Si

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N[C@@H]1CN(c2ccncc2[N+](=O)[O-])CC[C@H]1O[Si](C)(C)C(C)(C)C

HCID58386813

rel-1,1-Dimethylethyl N-[(3R,4R)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-(3-nitro-4-pyridinyl)-3-piperidinyl]carbamate

C21H36N4O5Si

收率 98%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

Method 1 was followed using 1 eq each of 4-chloro-3-nitropyridine, tert-butyl (3R,4R)-4-(tert-butyldimethylsilyloxy)piperidin-3-ylcarbamate and triethylamine in DMF yielding tert-butyl (3R,4R)-4-(tert-butyldimethylsilyloxy)-1-(3-nitropyridin-4-yl)piperidin-3-ylcarbamate, (98%). LCMS (m/z): 453.3 (MH+); LC Rt=4.01 min.