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HRID73523

反应详情

EQUATION

反应方程式

HRID 73523 的结构方程式

REACTANTS

反应物

3
结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

结构：O=[N+]([O-])c1cnccc1Cl
HCID2735781

4-Chloro-3-nitropyridine

C5H3ClN2O2

结构：CO[C@@H]1CCNC[C@H]1N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C
HCID86644734

未命名化合物

PRODUCTS

生成物

1
结构：CO[C@@H]1CCN(c2ccncc2[N+](=O)[O-])C[C@H]1N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C
HCID86644733

未命名化合物

收率 59%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

Method 1 was followed using trans (+/−)-3-(bis(tert-butoxycarbonyl)amino)-4-methoxypiperidine (1.0 equiv.), 4-chloro-3-nitropyridine (1.2 equiv.), and DIEA (4.0 equiv.) to give trans (+/−)-N,N-di-BOC-4-methoxy-1-(3-nitropyridin-4-yl)-piperidin-3-amine after column chromatography (EtOAc and hexanes, 50%) in 59% yield for two steps. LCMS (m/z): 453.2 (MH+), LC Rt=3.24 min.