Sodium hydride → HCID 67021037, compound

HRID 735415Notes

Reaction equation

HRID 735415 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][N:8]=[C:7]2[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][C:12]=1[CH3:19].[H-].[Na+].[CH2:22](I)[CH2:23][CH3:24]>>[Cl:1][C:2]1[C:10]2[C:6](=[C:7]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][C:12]=3[CH3:19])[N:8]([CH2:22][CH2:23][CH3:24])[N:9]=2)[CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 336431-IodopropaneHCID 178489140HCID 178489140, compound

Product 1

HCID 67021037HCID 67021037, compoundYield 34.2%

Procedure

Prepared according to Example 101 from 7-chloro-3-(4-methoxy-2-methylphenyl)-1H-indazole (0.150 g, 0.52 mmol), sodium hydride (60% in oil, 0.025 g, 1.04 mmol) and 1-propyl iodide (0.07 mL, 0.7 mmol) to give the title compound (0.056 g) as a white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-059eb7acea824dff824e1dfc4f12acd7
Source dataset
uspto-grants-2009_09
Patent number
US07592363B2

Reaction notes

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