Hydrazine hydrate (1:1) → HCID 178489142, compound

HRID 735425Notes

Reaction equation

HRID 735425 reaction equation
F[C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]([C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=1)=O.O.[NH2:20][NH2:21]>CN(C1C=CN=CC=1)C>[F:8][C:7]1[CH:6]=[CH:5][CH:4]=[C:3]2[C:2]=1[NH:21][N:20]=[C:9]2[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 62650974(2,3-Difluorophenyl)(4-methoxyphenyl)methanone

Product 1

HCID 178489142HCID 178489142, compoundYield 79.7%

Reagents, catalysts & solvents 1

HCID 142844-(Dimethylamino)pyridineCatalyst

Procedure

Prepared as in Example 104 from (2,3-difluorophenyl)-(4-methoxy-phenyl)-methanone (1.1 g, 4.4 mmol), hydrazine hydrate (1.37 mL, 44 mmol) and DMAP (0.54 g, 4.4 mmol) to give the product (0.85 g) as a white solid.

Sources & evidence

ORD record
ord-213803fdd9704bfc9534d29da1eaee7a
Source dataset
uspto-grants-2009_09
Patent number
US07592363B2

Reaction notes

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