Hydrazine hydrate (1:1) → HCID 178489136, compound

HRID 735427Notes

Reaction equation

HRID 735427 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1[C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[C:14]=1F)=O.O.[NH2:25][NH2:26]>CN(C1C=CN=CC=1)C>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1[C:11]1[C:13]2[C:14](=[C:15]([C:19]([F:22])([F:21])[F:20])[CH:16]=[CH:17][CH:18]=2)[NH:26][N:25]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 67021176(2,4-Dimethoxyphenyl)[2-fluoro-3-(trifluoromethyl)phenyl]methanone

Product 1

HCID 178489136HCID 178489136, compoundYield 37.2%

Reagents, catalysts & solvents 1

HCID 142844-(Dimethylamino)pyridineCatalyst

Procedure

Prepared as in Example 104 from (2,4-dimethoxyphenyl)[2-fluoro-3-(trifluoromethyl)phenyl]methanone (1.50 g, 5.17 mmol), hydrazine hydrate (1.61 mL, 51.7 mmol) and DMAP (0.632 g, 5.17 mmol) to give the product (0.619 g) as a yellow solid.

Sources & evidence

ORD record
ord-63bbc9a7bc8e4611875602caf92d36a2
Source dataset
uspto-grants-2009_09
Patent number
US07592363B2

Reaction notes

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