Hydrazine hydrate (1:1) → HCID 178489135, compound

HRID 735428Notes

Reaction equation

HRID 735428 reaction equation
F[C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][C:3]=1[C:12]([C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][C:15]=1[CH3:22])=O.O.[NH2:24][NH2:25]>CN(C1C=CN=CC=1)C>[CH3:21][O:20][C:17]1[CH:18]=[CH:19][C:14]([C:12]2[C:3]3[C:2](=[C:7]([C:8]([F:11])([F:10])[F:9])[CH:6]=[CH:5][CH:4]=3)[NH:25][N:24]=2)=[C:15]([CH3:22])[CH:16]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 67021619[2-Fluoro-3-(trifluoromethyl)phenyl](4-methoxy-2-methylphenyl)methanone

Product 1

HCID 178489135HCID 178489135, compoundYield 41.3%

Reagents, catalysts & solvents 1

HCID 142844-(Dimethylamino)pyridineCatalyst

Procedure

Prepared as in Example 104 from [2-fluoro-3-(trifluoromethyl)phenyl](4-methoxy-2-methylphenyl)methanone (1.34 g, 4.90 mmol), hydrazine hydrate (1.61 mL, 51.7 mmol) and DMAP (0.632 g, 5.17 mmol) to give the product (0.620 g) as a yellow solid.

Sources & evidence

ORD record
ord-227978148ecf45c8b4b7cc564fbde137
Source dataset
uspto-grants-2009_09
Patent number
US07592363B2

Reaction notes

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