Hydrazine hydrate (1:1) → HCID 178489140, compound

HRID 735430Notes

Reaction equation

HRID 735430 reaction equation
F[C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]([C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][C:12]=1[CH3:19])=O.O.[NH2:21][NH2:22]>CN(C1C=CN=CC=1)C>[Cl:8][C:7]1[CH:6]=[CH:5][CH:4]=[C:3]2[C:2]=1[NH:22][N:21]=[C:9]2[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][C:12]=1[CH3:19]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 65313555HCID 65313555, compound

Product 1

HCID 178489140HCID 178489140, compoundYield 49.7%

Reagents, catalysts & solvents 1

HCID 142844-(Dimethylamino)pyridineCatalyst

Procedure

Prepared as in Example 104 from [2-fluoro-3-chlorophenyl](4-methoxy-2-methylphenyl)methanone (1.26 g, 4.52 mmol), hydrazine hydrate (1.61 mL, 51.7 mmol) and DMAP (0.632 g, 5.17 mmol) to give the product (0.613 g) as a yellow solid.

Sources & evidence

ORD record
ord-e8a6099d411a493799cd7b37bca41944
Source dataset
uspto-grants-2009_09
Patent number
US07592363B2

Reaction notes

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