反应详情

温度

60 °C

4-(2-Benzyl-7-trifluoromethyl-2H-indazole-3-yl)-phenol (10 mg, 1 eq) was treated with benzylbromide (10 μL, 3 eq) and potassium carbonate (19 mg, 5 eq) in acetone (1 mL). The reaction mixture was heated at 60° C. until completion of the reaction, as judged by TLC. Volatiles were removed in vacuo and the residue treated with a water/dichloromethane mixture followed by extraction with dichloromethane. Purification by flash chromatography (silica, ethyl acetate/n-heptane, 1:9) gave the title compound in 89% yleld.

1. customVolatiles were removed in vacuo
2. additionthe residue treated with a water/dichloromethane mixture
3. extractionfollowed by extraction with dichloromethane
4. customPurification by flash chromatography (silica, ethyl acetate/n-heptane, 1:9)