反应详情

A solution of 25A (750 mg, 2.3 mmol) and 23B (486 mg, 4.5 mmol) with potassium carbonate (627 mg, 2.3 mmol) in DMF (6 mL) were heated at 50° C. for 15 h. The mixture was diluted with water (100 mL) and extracted with EtOAc (3×100 mL). The organics were washed with brine, dried over Na2SO4 and concentrated. The crude product was purified by flash chromatography (0% to 100% EtOAc in hexanes) to yield give 25B (950 mg, 93%) as a colorless oil. MS (ESI) m/z 449.89/451.91 (M+H)+.

1. extractionextracted with EtOAc (3×100 mL)
2. washThe organics were washed with brine
3. dry with materialdried over Na2SO4
4. concentrationconcentrated
5. customThe crude product was purified by flash chromatography (0% to 100% EtOAc in hexanes)
6. customto yield