HRID735574

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCS(=O)(=O)c1ccc(NC(=O)N(C)CCc2ccc(C(Nc3cccc(C(N)=O)c3)C(=O)O)cc2)cc1CNC(=O)OCc1ccccc1

HCID57842918

未命名化合物

PRODUCTS

生成物

结构：CCS(=O)(=O)c1ccc(NC(=O)N(C)CCc2ccc(C(Nc3cccc(C(N)=O)c3)C(=O)O)cc2)cc1CN

HCID57842602

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID313

Hydrochloric Acid

ClH

溶剂HCID19895526

未命名化合物

PROCEDURE

实验过程

A solution of 28G (225 mg, 0.32 mmol) in THF/MeOH/EtOAc (1:1:1) and HCl (1.0 M, 1.5 mL) with Pd/C (50 mg, 10%) was stirred under H2 (60 psi) for 20 h. The mixture was filtered through Celite and concentrated in vacuo to yield 28H (160 mg, 83%). MS (ESI) m/z 568.3 (M+H)+.

WORKUP

后处理

filtrationThe mixture was filtered through Celite
concentrationconcentrated in vacuo
customto yield 28H (160 mg, 83%)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-139ff56184b146bbbceb2dd0caa2c28d
来源数据集: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07592331B2
来源说明: uspto-grants-2009_09

反应 SMILES

C(OC([NH:11][CH2:12][C:13]1[CH:14]=[C:15]([NH:24][C:25](=[O:50])[N:26]([CH2:28][CH2:29][C:30]2[CH:35]=[CH:34][C:33]([CH:36]([NH:40][C:41]3[CH:46]=[CH:45][CH:44]=[C:43]([C:47](=[O:49])[NH2:48])[CH:42]=3)[C:37]([OH:39])=[O:38])=[CH:32][CH:31]=2)[CH3:27])[CH:16]=[CH:17][C:18]=1[S:19]([CH2:22][CH3:23])(=[O:21])=[O:20])=O)C1C=CC=CC=1>C1COCC1.CO.CCOC(C)=O.Cl.[Pd]>[NH2:11][CH2:12][C:13]1[CH:14]=[C:15]([NH:24][C:25](=[O:50])[N:26]([CH2:28][CH2:29][C:30]2[CH:35]=[CH:34][C:33]([CH:36]([NH:40][C:41]3[CH:46]=[CH:45][CH:44]=[C:43]([C:47](=[O:49])[NH2:48])[CH:42]=3)[C:37]([OH:39])=[O:38])=[CH:32][CH:31]=2)[CH3:27])[CH:16]=[CH:17][C:18]=1[S:19]([CH2:22][CH3:23])(=[O:21])=[O:20]